Methampirone, Thiamine HCl, Pyridoxine HCl, Cyanocobalamin, Trimethylxanthine.

Each film coaterd caplet contains :

Methampyrone                                     500 mg

Thiamine HCl                                                     50 mg

Pyridoxine HCl                                       10 mg

Cyanocobalamin                                                  10 mg

Trimethylxanthine                                                 50 mg

Methampyrone is a potent nonnarcotic analgesic – antipyretic drug. It is a pyrazolon derivative with therapeutic efficacy equivalent to that of acetosal, the standard drug for  the nonnarcotic analgesic – antipyretic class. It cause less gastric irritation that acetosal and does not produce the acid – base or metabolic effect of salicylate.

Hewever, it has been implicated for many heares to cause a high incident of agranulocytosis. An epidemiologic study of international scale involving about 30 million people had been especially designed to study this matter.

The study was completed just recently and the results showed that methampurone , in fact, accounted for only a very low incidence of agranulocytosis.

Trimethylxanthine is commonly added to an analgesic as an analgesic adjuvant. In a dose of 50 mg or more, trimethylxanthine has been shown to enhance the analgesic efficacy of acetosal adan acetaminophen; in this case methampyrone should not be an exception.

Thiamine HCl, pyridoxine HCl and cyanocobalamin are neurotropic vitamins; deficiency of any of these vitamins may cause some form of neurologic disturbance.

INDICATIONS

Relief of mild to severe pain, such as headache especially tension headache, myalgia, arthralgia, neuralgia, lumbago, tootache, menstrual pain, pain from cancer, biliary and renal colic, postpartum pain, postoperative pain.

CONTRAINDICATION

PRECAUTIONS

- hemostatic defect (avoid) or anticoagulant therapy

- severe liver disease

- pregnancy (not recommended) especially late pregnancy.

- nursing mother (not recommended)

- infants

- history of blood dyscasia.

             

The most frequent are gastrointestinal symtoms, such as nausea, vomiting, epigastric discomfort etc.

NERUALGIN RX may also cause hypersensitivity reactions, e.g. skin rashes and pruritus. Side effect occuring rarely are gastrointestinal bleeding and ulceration, leukopenia and agranulcytosis.

DOSAGE

Adult                : 1-2 caplets 3 to 4 times daily

Children           : ½ -1 caplet 3 to 4 times daily

If gastrointestinal discomfort occurs, administer NEURALGIN RX with or after meals

STORAGE

Sore below 30⁰C

Box of 10 strips x 10 film coated caplets.

Reg.No. DKL8511603809A1

PT KALBE FARMA