ASPAR-K supplement potassium aspartate
ASPAR-K
Potassium aspartate preparation
COMPOSITION AND DESCRIPTION
Generic name : Potassium L-aspartate
Product’s name
|
Content of Potassium
L-aspartate
|
Description of the product
|
ASPAR-K
|
300 mg per tablet (K : 1,8 mEq)
|
White film-coated tablet
|
ACTIONS
PHARMACOLOGICAL ACTIONS :
A potassium ion, one of the main electrolytes in the cell,
has actions such as to induce the membrane potential, to maintain the osmotic
pressure and to control the acid-base equilibrium.
When the red blood cell is employed as a sample to examine
the transport of potassium into the tissues, potassium L-aspartate proves a
beter intake by the tissues than potassium chloride.
ABSORPTION AND EXCRETION :
When the amount of Potassium L-aspartate equivalent to 20
mEq/kg/day of potassium was administered for 32 days to rats fed on food
lacking porassium for 24 days, the eman amount of potassium excreted in the
feces was 26.1 µEq/head/day.
Namely, the absorption rate of potassium from the intestines was not less than
99,5% because the mean administration amount of potassium was 5,497 µEq/head/day.
TOXICOLOGY AND TERATOLOGY
1.
Acute toxicity :
The LD50 of Potassium L-aspartate in male
rats is not less than 10000 mg/kg, 4,061 mg/kg, 1500 mg/kg and 667 mg/kg by
oral, subcutaneous, intraperitoneal and intravenous routes, respectively.
2.
Chronic toxicity :
After administration fo 4g/kg
3.
Teratology
Fetal toxicity in mice and rats was evaluated
in accordance with the Measurements for Safety of Drug by the Japanese Ministry
of Health & Welfare, and no significant difference was observed between
administration and control group.
INDICATIONS
Potassium supplement in the following diseases and symptoms
accompanied with the imbalance of electrolytes :
Cardiac diseases
Liver diseases
Periodic tetraplegia due to hypokalemia,
Hypokalemia due to prolonged administration of antihypertensi
diuretics, adrenal cortical steroid, digitalis and insulin
Other disorder of potassium metabolism (pre- and
post-operative course, diarrhea, vomiting)
ADMINISTRATION AND DOSAGE
Take 1 to 3 tablets three times daily
The dose may be increased according to the secerity of
symptoms and condition of patients.
CAUTION ON USE
1.
CONTRAINDICATION :
1)
Patiens with Addison;s
disease untreated
2)
Patient with hyperkalemia
3)
Patient with
hypersensitivity to the drug components
2.
USES WITH CAUTION
On administration to those patiens with
advanced hypo functioned or damaged kidneys, including those suspected of such
disorders, whose serum and urnary electrolytes should be carefully examined.
3.
ADVERSE REACTION :
a.
Digestive system : anorexia and gastric disturbances have
been encountered.
b.
Heart : precordial heavy feeling
has been noted.
4.
IT IS ADVISABLE NOT TO
ADMINISTER THE DRUG to premature infants, newborns and infats, because the
drug is reported to cause at 250 mg/kg or more as asparticc acid some
histopathological change in the nucleous arciformis of the hypothalamus in mice
and rats at the age of 3 week or below.
5.
INTERACTION :
Since the following drug may cause
hyperkalemia, concurent use with the should be exercised with much care
·
Antialdosterone preparation
·
triamterene
CAUTION AND HANDLING
As the tablet are hygroscopic the container and tablet must
be kept in a cool and dry place
STORAGE
Store in a tigh and light-resistent container at below 300C
PRESENTATION
Box of 10 aluminium strips of 10 tablets
MITSUBISHI TANABE PHARMA CORPORATION
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